The sliders track Rickman to a world where a mad scientist has been experimenting with genetic testing and has created a race of human hybrids.
Wade becomes infatuated with Stoker, a rock band whose members are secretly vampires. Meanwhile, the other sliders try to find clues to Rickman’s whereabouts before he escapes them again.
The sliders arrive back at the New World they helped Rickman colonise, shortly after the Colonel arrives himself. While the sliders try to figure out how to stop Rickman, they discover this parallel world’s unusual inhabitants: dinosaurs, including a particularly aggressive Tyrannosaurus Rex.
Quinn and Rembrandt head down to Mexico to blow off a little steam. Getting back into the United States turns out to be a bit of a problem when they get mixed up in an illegal snake trade and find themselves stuck in the middle of a jungle, surrounded by deadly snakes and the tobacco cartel. Meanwhile, Wade and Maggie run into problems of their own while they search for their friends.
The sliders finally track Rickman down in a town bordered by a sulfurous fog. When Quinn and Maggie are captured, Quinn is forced to confront a familiar face.
Wade and Rembrandt recall a particularly harrowing adventure on a world at the mercy of catastrophic earthquakes. When Wade falls beneath the earth, Quinn embarks on a risky rescue mission while Rembrandt and Arturo fall into the company of the less-than-friendly natives.
The sliders narrowly escape from a world filled with parasitic creatures, but not before Maggie becomes infected. On the next world, the parasite searches for a host in order to reproduce.
At long last, Quinn has the coordinates to Earth Prime, but its atmosphere is deadly to Maggie and her people. While Quinn and Maggie continue to search for a hospitable world, Wade works to perfect the Slide list to Rickman’s specifications and Arturo tries to modify the timer to save more people.
The sliders arrive on a doomed world. When a pulsar collapses, it sends destructive radiation towards Earth. Now the Sliders have to work with the US military in a race against time to escape this world. Meanwhile, a savage killer lurks in the base, and if the sliders aren’t careful, he may follow them to the next world!
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